https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Finding needles in haystacks: the use of quantitative proteomics for the early detection of colorectal cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46915 Wed 07 Dec 2022 09:37:40 AEDT ]]> Tumor innervation and clinical outcome in pancreatic cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43873 Tue 04 Oct 2022 12:29:00 AEDT ]]> The membrane protein sortilin can be targeted to inhibit pancreatic cancer cell invasion https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37858 P = 0.0014). Sortilin inhibition by siRNA and the pharmacologic inhibitor AF38469 strongly reduced the adhesion and invasion of pancreatic cancer cells without affecting cell survival and viability. Sortilin inhibition also decreased the phosphorylation of the focal adhesion kinase in Tyr925. Together, these data show that sortilin contributes to pancreatic cancer invasion and could eventually be targeted in therapy.]]> Thu 24 Mar 2022 11:34:45 AEDT ]]>